Mechanisms of Synergistic Skin Penetration by Sonophoresis and Iontophoresis
نویسندگان
چکیده
منابع مشابه
The combination of microneedles with electroporation and sonophoresis to enhance hydrophilic macromolecule skin penetration.
The objective of the present work was to investigate the effects of 3 combinatorial techniques (microneedle (MN), electroporation (EP), and sonophoresis (SN)) on the in vitro skin permeation of the hydrophilic macromolecular compound fluorescein isothiocyanate-dextran (FD-4; molecular weight (MW) 4.4 kDa). Assessment of the in vitro skin permeation of FD-4 was performed in porcine skin. MN, EP,...
متن کاملAblative Fractional Radiofrequency Combined with Sonophoresis Increases Skin Penetration of Indocyanine Green
Vol. 27, No. 3, 2015 343 Received August 29, 2013, Revised June 26, 2014, Accepted for publication July 20, 2014 Corresponding author: Min Kyung Shin, Department of Dermatology, Kyung Hee University College of Medicine, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-872, Korea. Tel: 82-2-958-8300, Fax: 82-2-969-6538, E-mail: [email protected] This is an Open Access article distributed under the t...
متن کاملMechanistic study of decreased skin penetration using a combination of sonophoresis with sodium fluorescein-loaded PEGylated liposomes with d-limonene.
The effect of low frequency sonophoresis (SN, 20 kHz) on the skin transport of sodium fluorescein (NaFI)-loaded liposomes was investigated. An in vitro skin penetration study in open and blocked hair follicles was performed, and confocal laser scanning microscopy and scanning electron microscopy were used to visualize the penetration pathways. The results showed that SN significantly increased ...
متن کاملVasoactive properties of lignocaine administered by iontophoresis in human skin.
The vasoactivity of lignocaine has an important influence on its clinical efficacy and systemic vascular absorption. The aim of this study was to evaluate its vasoactive properties when administered by the non-invasive technique of iontophoresis. We used laser Doppler imaging to measure the forearm skin blood flow responses of seven healthy young males to iontophoretic delivery of two preparati...
متن کاملSynergistic Effect of Chemical Enhancer And Iontophoresis For Transdermal Delivery Of Nebivolol Hydrochloride
The aim of the present study was to develop and investigate the feasibility of delivering Nebivolol as a transdermal patch by iontophoresis. The passive and electrically assisted transdermal delivery of Nebivolol hydrochloride by iontophoresis will improve the therapeutic efficacy and overcome the difficulties raised in oral drug delivery. Because of its extensive hepatic metabolism and low dos...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2009
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.32.905